You will find there's launch of norepinephrine with the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors while in the dorsal horn to lower afferent discomfort transmission and produce analgesia. For that reason, medications like clonidine that goal alpha-2 receptors can impact the transmission of pain. Relates to clonidine: https://socialbaskets.com/story5410629/onolidine-an-overview